Avastin in metastatic breast cancer

Disclosures: Ricardo H. Significant advances in the treatment of patients with breast cancer have been made in the past 10 years. The current systemic treatment of breast cancer is characterized by the discovery of multiple cancer targets leading to treatments that are more sophisticated and specific than conventional cytotoxic chemotherapy. Two classes of compounds that have helped improve clinical outcomes are small molecules and monoclonal antibodies targeting specific tyrosine kinase receptors. Many novel targets have been discovered, and parallel multiple approaches to anticancer therapy have recently emerged from the literature.
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Bevacizumab in the Treatment of Metastatic Breast Cancer: Friend or Foe?

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The US FDAs withdrawal of the breast cancer indication for Avastin (bevacizumab)

On November 18, , the US Food and Drug Administration US FDA announced that breast cancer indication for Avastin bevacizumab had been withdrawn after concluding that the drug has not been shown to be safe and effective for the treatment of breast cancer. The specific indication that was withdrawn was for the use of bevacizumab in metastatic breast cancer, with paclitaxel for the treatment of patients who have not received chemotherapy for metastatic HER2-negative breast cancer. The US FDAs decision has been met with emotion and confusion among the public and health professionals. The purpose of this article is to review the regulatory history of bevacizumab for breast cancer and to examine the scientific evidence that led to the approval and subsequent withdrawal of this indication.
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Bevacizumab in Metastatic Breast Cancer: Ready for Prime Time?

Avastin chemical name: bevacizumab is a targeted therapy that was approved by the U. Food and Drug Administration FDA in combination with Taxol chemical name: paclitaxel in February to treat people with metastatic HER2-negative breast cancer who haven't yet received chemotherapy for metastatic breast cancer. On Nov.
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